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Pannexin1 channels in the liver: an open enemy

Raf Van Campenhout1, Anne Caufriez1, Andrés Tabernilla1

  • 1Entity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

Frontiers in Cell and Developmental Biology
|July 26, 2023
PubMed

Insights

Pannexin1 (Panx1) channels facilitate cell communication and are implicated in numerous diseases. This review focuses on Panx1

Area of Science:

  • Cell biology
  • Molecular biology
  • Physiology

Background:

  • Pannexin1 (Panx1) proteins form cell surface channels.
  • These channels mediate the exchange of ions and small molecules.
  • Panx1 channel activity is linked to various cellular functions and pathologies.

Purpose of the Study:

  • To review and summarize the structure, life cycle, and regulation of Panx1 channels.
  • To explore the physiological and pathophysiological roles of Panx1.
  • To specifically highlight the involvement of Panx1 in liver diseases.

Main Methods:

  • Literature review and synthesis.
  • Analysis of existing research on Pannexin1.
  • Focus on studies related to liver pathophysiology.

Main Results:

  • Pannexin1 channels are crucial for intercellular communication.
  • Dysregulation of Panx1 is associated with diverse human diseases.
  • Significant evidence links Panx1 activity to the progression of liver diseases.

Conclusions:

  • Pannexin1 channels are key players in cellular processes and disease.
  • Understanding Panx1 structure, function, and regulation is vital.
  • Pannexin1 represents a potential therapeutic target, particularly in liver disease contexts.
Keywords:
cell deathinflammationliver diseasepannexin1pathologyphysiology

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