Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic differences in locomotor activation in mice.

J C Crabbe

    Pharmacology, Biochemistry, and Behavior
    |July 1, 1986
    PubMed
    Summary

    Genetic factors significantly influence mouse behavior, including habituation and responses to ethanol. A single gene appears to control habituation, highlighting the importance of genetic specificity in neuropharmacologic studies using mice.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents.

    International review of neurobiology·2016
    Same author

    Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication.

    Genes, brain, and behavior·2016
    Same author

    Nest building is a novel method for indexing severity of alcohol withdrawal in mice.

    Behavioural brain research·2016
    Same author

    Distinct ethanol drinking microstructures in two replicate lines of mice selected for drinking to intoxication.

    Genes, brain, and behavior·2015
    Same author

    Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice.

    Genes, brain, and behavior·2013
    Same author

    Translational behaviour-genetic studies of alcohol: are we there yet?

    Genes, brain, and behavior·2012

    Area of Science:

    • Behavioral Neuroscience
    • Genetics
    • Pharmacology

    Background:

    • Habituation of activity and responses to acute ethanol injections vary among inbred mouse strains.
    • Understanding the genetic basis of these behavioral differences is crucial for interpreting neuropharmacologic studies.

    Purpose of the Study:

    • To investigate the genetic underpinnings of habituation in mouse activity.
    • To examine strain-specific responses to acute ethanol administration in mice.

    Main Methods:

    • Assessed habituation of activity in a toggle-box exploration task using two highly inbred mouse strains and their recombinant inbred (RI) strains.
    • Administered acute ethanol injections and measured open-field activity across 19 different inbred mouse strains.

    Main Results:

    • A single gene appears to significantly influence habituation of activity, with RI strains resembling one of the parent strains.
    • Ethanol's effect on activity differed significantly across the 19 inbred strains, with some showing decreased activity, others increased, and some no change.

    Conclusions:

    • Genetic specificity plays a critical role in the interpretation of pharmacologic substrates for activity in mice.
    • Lines of mice selectively bred for high and low open-field activity are recommended for future neuropharmacologic research.

    Related Experiment Videos