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Related Experiment Video

Updated: Jul 21, 2025

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
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A Beginner's Guide to Arterial Spin Labeling (ASL) Image Processing.

Patricia Clement1, Jan Petr2,3, Mathijs B J Dijsselhof3,4

  • 1Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.

Frontiers in Radiology
|July 26, 2023
PubMed
Summary
This summary is machine-generated.

This review simplifies arterial spin labeling (ASL) MRI processing for brain perfusion analysis. It provides educational guidance on ASL image processing steps, accelerating research and clinical applications.

Keywords:
MRIarterial spin labelingcerebral blood flowgraphical user interfaceimage processingperfusionprocessing pipeline

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Area of Science:

  • Neuroimaging
  • Medical Imaging Analysis
  • Cerebrovascular Physiology

Background:

  • Arterial spin labeling (ASL) is a valuable non-invasive MRI technique for measuring brain perfusion.
  • Despite its utility, ASL image processing remains complex and a barrier to wider adoption.
  • Educational gaps exist, particularly in post-acquisition processing for statistical analyses.

Purpose of the Study:

  • To provide an educational review of ASL image processing and analysis.
  • To demystify the post-acquisition steps for both single-subject and group-level analyses.
  • To accelerate the use of ASL MRI in research and clinical practice through improved understanding.

Main Methods:

  • Summarizes typical ASL processing steps, from basic principles to advanced analysis.
  • Includes explanations of ASL physiology and MRI technique interactions.
  • Utilizes example illustrations and model calculations for practical understanding.

Main Results:

  • Provides a comprehensive overview of ASL processing pipelines.
  • Explains specific ASL processing steps with visual aids.
  • Offers guidance on checking processing steps for individual analyses.

Conclusions:

  • This educational review aims to simplify ASL image processing.
  • It is intended for researchers and clinicians interested in brain perfusion analysis.
  • The review is expected to facilitate broader application of ASL MRI in clinical brain research.