Related Experiment Video

Updated: Jul 21, 2025

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

3.9K

Transcatheter edge-to-edge repair for mitral regurgitation using PASCAL or MitraClip

Ayman Elbadawi1, Alexander T Dang2, Mohamed Hamed3

  • 1Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|July 26, 2023
PubMed
Abstract

Insights

Mitral valve transcatheter edge-to-edge repair (MTEER) using PASCAL or MitraClip systems shows similar short-term efficacy and safety for mitral regurgitation. Further randomized trials are needed to assess long-term outcomes of these MTEER devices.

Area of Science:

  • Interventional Cardiology
  • Medical Devices
  • Cardiovascular Surgery

Background:

  • Limited comparative data exists for Mitral valve transcatheter edge-to-edge repair (MTEER) devices, specifically the PASCAL and MitraClip systems, in treating mitral regurgitation (MR).
  • Understanding the comparative efficacy and safety profiles of these MTEER systems is crucial for clinical decision-making.

Approach:

  • A comprehensive electronic literature search was performed across MEDLINE, COCHRANE, and EMBASE databases up to February 2023.
  • Six studies encompassing 1581 patients with severe MR were included in a random-effects model meta-analysis.
  • The primary outcome assessed was residual MR ≤ 2 at discharge, with secondary outcomes including procedural success and adverse events.

Key Points:

  • No significant differences were observed in residual MR ≤ 2 at discharge or mid-term follow-up between PASCAL and MitraClip systems.
  • While residual MR ≤ 1 at discharge was similar, the PASCAL system showed a greater incidence of residual MR ≤ 1 at mid-term follow-up.
  • Technical success, procedural success, single leaflet detachment, and all-cause mortality rates were comparable between the two MTEER systems.

Conclusions:

  • The meta-analysis indicates comparable short- and mid-term efficacy and safety between the PASCAL and MitraClip MTEER systems.
  • Randomized controlled trials are necessary to definitively evaluate and compare the long-term clinical outcomes of these leading MTEER devices.
Keywords:
MTEERMitraClipPASCALmitral regurgitation

More Related Videos

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

1.7K
Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China08:42

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Published on: February 11, 2022

3.5K

Related Concept Videos

Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
18
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
13
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
18
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
49
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
23
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
23