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Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between

Jared G Maina1,2, Zhanna Balkhiyarova3,4,5, Arie Nouwen6

  • 1INSERM UMR 1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, France.

Diabetes Care
|July 26, 2023
PubMed
Summary

Depression causally increases type 2 diabetes risk, with BMI mediating a significant portion of this effect. Preventing depression and managing weight are key for managing this comorbidity.

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