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Updated: Jul 21, 2025

Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation
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The rise of degrader drugs

Mingxing Teng1, Nathanael S Gray2

  • 1Center for Drug Discovery, Department of Pathology & Immunology, and Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Cell Chemical Biology
|July 26, 2023
PubMed

Insights

Targeted protein degradation (TPD) offers a novel therapeutic approach by using small molecules to eliminate disease-causing proteins. This field is rapidly advancing, with numerous TPD drugs entering clinical trials for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Cancer genomics has identified numerous therapeutic targets.
  • Targeted protein degradation (TPD) is an emerging modality that hijacks cellular machinery to degrade proteins.
  • Over 20 TPD molecules targeting more than 12 proteins are in clinical development.

Purpose of the Study:

  • To provide a high-level evaluation of recent advancements in targeted protein degradation.
  • To discuss strategies for realizing the full therapeutic potential of TPD.
  • To highlight the potential for a "Gleevec moment" in TPD drug development.

Main Methods:

  • Review of current literature and clinical trial data in targeted protein degradation.
  • Analysis of the progress and challenges in developing novel protein degraders.
  • Evaluation of the clinical validation of TPD based on existing drug classes like IMiDs.

Main Results:

  • Significant progress in the rational design and development of TPD molecules.
  • Successful clinical entry of numerous TPD candidates.
  • Established precedent for TPD through immunomodulatory drugs (IMiDs) in multiple myeloma.

Conclusions:

  • The field of targeted protein degradation is rapidly maturing.
  • TPD holds significant promise as a new therapeutic modality for cancer treatment.
  • Further development and clinical validation are crucial to establish TPD's full potential.

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