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Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
Metabolic-Associated Fatty Liver Disease in Childhood and Adolescence
Carolyn Vespoli1, Anoop Mohamed Iqbal2, Mohammad Nasser Kabbany1
1Cleveland Clinic Children's Department of Pediatric Gastroenterology Hepatology and Nutrition, 8950 Euclid Avenue, R Building, Cleveland, OH 44195, USA.
Abstract:
Metabolic-associated fatty liver disease (MAFLD) has become the most common cause for chronic liver disease among children and adolescents globally. Although liver biopsy remains the gold standard for diagnosis, emerging technology, like velocity controlled transient elastography, a noninvasive method, is being utilized to evaluate degree of fibrosis in these patients. The discovery of multiple gene polymorphisms has brought new hope for possible treatment targets. However, this research is still ongoing, making lifestyle changes and weight reduction the current mainstay of treatment. This review briefly reviews the most recent data regarding the epidemiology, pathophysiology, diagnostic modalities, and treatment of pediatric MAFLD.
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