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Updated: Jul 21, 2025

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Recurrent Stroke with Rapid Development of Intracranial Artery Stenosis and Subsequent Successful Mechanical

Yuji Kato1, Shohei Iijima2, Shinya Kohyama2

  • 1Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan.

Internal Medicine (Tokyo, Japan)
|July 26, 2023
PubMed

Essential thrombocythemia is a myeloproliferative neoplasm. Ischemic stroke is frequently the first manifestation of essential thrombocythemia. We herein report a patient with JAK2V617 mutation-positive essential thrombocythemia who developed recurrent ischemic stroke with rapid development of intracranial artery stenosis and subsequently underwent successful mechanical thrombectomy. The high JAK2V617F allele burden in our patient (58.4%) may have affected the patient's condition. We discuss similar reports in the literature and the possible pathophysiologic mechanism of large artery involvement in these patients.

Keywords:
JAK2V617 allele burdenearly/prefibrotic primary myelofibrosisessential thrombocythemiahistopathology

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