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Updated: Jul 21, 2025

Author Spotlight: Microfluidic Channel-Based Soft Electrodes and Their Application in Capacitive Pressure Sensing

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Published on: March 17, 2023

Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design.

Yang Li¹, Nan Li¹, Wei Liu¹

¹Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, 60637, USA.

Nature Communications

|July 26, 2023

Summary

This summary is machine-generated.

Researchers developed a soft interlayer to make existing stretchable electronics ultra-soft and highly conformable to biological tissues. This innovation enables advanced bioelectronic devices with improved performance and biocompatibility for medical applications.

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Area of Science:

Materials Science
Biomedical Engineering
Electronics

Background:

Soft and stretchable electronics offer great potential for biomedical applications due to their ability to interface with biological systems.
Current stretchable electronics often have high Young's moduli, limiting their conformability and biocompatibility with soft biological tissues.

Purpose of the Study:

To present a novel soft interlayer design strategy for creating stretchable electronic devices with ultralow tissue-level moduli.
To overcome the limitations of existing materials and enhance the conformability and biocompatibility of bioelectronic devices.

Main Methods:

Development of a soft interlayer to integrate with existing stretchable materials.
Fabrication of stretchable transistor arrays and active-matrix circuits using the soft interlayer design.
Testing of device conformability, electrophysiological recording on an isolated heart, and in vivo biocompatibility.

Main Results:

Demonstrated stretchable electronic devices with moduli below 10 kPa, significantly lower than the current state of the art.
Achieved high adaptability and spatial stability during electrophysiological recording on an isolated heart with minimal impact on ventricle pressure.
In vivo biocompatibility tests showed suppressed foreign-body responses, indicating suitability for long-term implantation.

Conclusions:

The soft interlayer design enables the creation of versatile, ultrasoft bioelectronic devices from existing stretchable materials.
This approach overcomes material limitations, imparting tissue-level softness crucial for advanced biomedical diagnosis and studies.
The developed technology holds promise for improving the performance and longevity of implantable bioelectronic devices.