Related Experiment Video

Updated: Jul 21, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Interstitial Nephritis: Wherefrom, Wherein, and Whereto

Garabed Eknoyan1

  • 1From the Selzman Institute of Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|July 27, 2023
PubMed

Insights

Interstitial nephritis, a key factor in chronic kidney disease, involves tubulointerstitial lesions. These fibrotic lesions strongly correlate with disease severity and progression, regardless of the initial cause.

Area of Science:

  • Nephrology
  • Pathology

Background:

  • Renal interstitial abnormalities were recognized early in chronic kidney disease (CKD) identification.
  • Historical focus shifted from interstitial to glomerular and vascular lesions.
  • Acute interstitial nephritis was defined in 1898, with chronic forms initially linked to pyelonephritis.

Purpose of the Study:

  • To trace the historical understanding and evolving definitions of interstitial nephritis.
  • To highlight the recognition of interstitial lesions as a primary cause of CKD.
  • To emphasize the significance of tubulointerstitial nephritis and its lesions.

Main Methods:

  • Historical literature review.
  • Analysis of diagnostic advancements, including kidney biopsy.
  • Examination of etiological factors such as analgesic nephropathy and vesico-ureteral reflux.

Main Results:

  • Interstitial lesions were identified as a primary cause of CKD following kidney biopsy in the 1950s.
  • The term tubulointerstitial nephritis (TIN) was introduced to encompass tubular involvement.
  • Fibrotic TIN lesions demonstrate a strong correlation with CKD severity and progression.

Conclusions:

  • Tubulointerstitial nephritis is a crucial entity in nephrology.
  • Fibrotic tubulointerstitial lesions are a key indicator of kidney disease progression.
  • Understanding TIN pathogenesis is vital for managing chronic kidney disease.

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