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Related Experiment Video

Updated: Jul 21, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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[Morphofunctional cerebral changes associated with development of suicidal behavior].

M A Kislov1, A N Prikhod'ko2, D S Trusova1

  • 1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Sudebno-Meditsinskaia Ekspertiza
|July 27, 2023
PubMed
Summary

Suicidal behavior is linked to significant structural and functional brain changes, particularly in the basal ganglia and cerebral cortex. Further research, including postmortem studies, is crucial for understanding these alterations.

Keywords:
cerebellummorphofunctional and functional changessuicidal behavior

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Area of Science:

  • Neuroscience
  • Neuropathology

Context:

  • Suicidal behavior is a complex phenomenon with underlying neurobiological correlates.
  • Identifying specific brain regions affected by suicidal behavior is critical for understanding its pathophysiology.

Purpose:

  • To identify cerebral areas exhibiting significant structural changes and altered functional activity in individuals with suicidal behavior.
  • To pinpoint the most significantly deviated brain structures associated with suicidal behavior.

Summary:

  • A literature review identified 69 cerebral regions with significant changes in suicidal behavior.
  • Key affected areas include basal ganglia (striatum, limbic system) and cerebral cortex (frontal, insular, cingulate, parietal regions).
  • Observed changes encompass reduced grey matter volume, altered neuronal/glial density, distinct activity patterns, and modified functional connectivity.

Impact:

  • Highlights the need for advanced neuroimaging and postmortem studies in completed suicide cases.
  • Provides a foundation for future research into the neurobiology of suicidal behavior.
  • Emphasizes the importance of studying specific brain structures like the basal ganglia and cerebral cortex in suicide research.