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Updated: Jul 21, 2025

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Serine/Threonine Protein Kinase-3 Promotes Oral Squamous Cell Carcinoma by Activating Ras-MAPK Mediated Cell Cycle

Li Yue1, Yuedi Xu1, Ping Lu1

  • 1Department of Stomatology, Liaocheng People's Hospital, Liaocheng, Shandong, 252000, People's Republic of China.

International Journal of General Medicine
|July 27, 2023
PubMed
Abstract

Insights

Serine/threonine protein kinase-3 (STK3) promotes oral squamous cell carcinoma (OSCC) progression by enhancing cell proliferation, migration, and invasion. Inhibiting STK3 may offer a therapeutic strategy for OSCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Serine/threonine protein kinase-3 (STK3) is a key component of the Hippo pathway.
  • The specific role of STK3 in oral squamous cell carcinoma (OSCC) development is not well understood.

Purpose of the Study:

  • To investigate the biological function and clinical significance of STK3 in OSCC.
  • To explore STK3 as a potential therapeutic target for OSCC.

Main Methods:

  • Analysis of STK3 expression in tumor patients using GEPIA.
  • Validation of STK3 expression in OSCC patient samples via qRT-PCR and Western blotting.
  • In vitro functional assays (overexpression and knockdown) to assess the impact of STK3 on cell proliferation, migration, and invasion.

Main Results:

  • STK3 is significantly upregulated in OSCC patients, correlating with poor prognosis.
  • STK3 overexpression enhances OSCC cell proliferation, migration, and invasion.
  • STK3 downregulation inhibits OSCC cell proliferation, migration, and invasion.
  • STK3 promotes OSCC progression by activating Ras-MAPK mediated cell cycle progression.

Conclusions:

  • STK3 acts as a potential oncogene in OSCC.
  • STK3 plays a crucial role in promoting oral squamous cell carcinoma progression.
  • Targeting STK3 presents a promising therapeutic avenue for OSCC treatment.
Keywords:
OSCCSTK3invasionmigrationoral squamous cell carcinoma cancerproliferationserine/threonine protein kinase-3

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