Polysaccharides from natural resource: ameliorate type 2 diabetes mellitus via regulation of oxidative stress network

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Updated: Jul 21, 2025

Extraction and Analysis of Taiwanese Green Propolis
06:50

Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

8.5K

Li-Ying He1, Yong Li1, Shu-Qi Niu2,3

  • 1Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in Pharmacology
|July 27, 2023
PubMed

Insights

Natural polysaccharides show promise for managing diabetes by combating oxidative stress. This review details their structures and mechanisms, offering insights for developing new diabetes treatments.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Nutrition Science

Background:

  • Diabetes mellitus (DM) is a metabolic disorder marked by hyperglycemia.
  • Oxidative stress is a key factor in the development of type 2 diabetes mellitus (T2DM) and metabolic syndrome.
  • Natural polysaccharides are complex carbohydrates with potential therapeutic benefits.

Purpose of the Study:

  • To summarize natural polysaccharides with therapeutic potential for diabetes over the last five years.
  • To elucidate the pharmacological mechanisms and primary structures of these polysaccharides.
  • To provide a reference for polysaccharide application and the development of novel anti-diabetic drugs.

Main Methods:

  • Literature review of natural polysaccharides and their effects on diabetes.
  • Analysis of studies published within the last five years.
  • Focus on structural characterization and pharmacological mechanisms.

Main Results:

  • Numerous natural polysaccharides from plants, microbes, marine organisms, and animals exhibit antioxidant and anti-diabetic properties.
  • Detailed structural information and mechanisms of action are increasingly being identified.
  • Polysaccharides demonstrate significant therapeutic potential in managing hyperglycemia and related complications.

Conclusions:

  • Natural polysaccharides represent a promising avenue for diabetes management.
  • Further research into their structures and mechanisms can accelerate the development of new anti-diabetic therapies.
  • This review consolidates current knowledge, aiding future drug discovery efforts.
Keywords:
diabetes mellitusmechanismmetabolismnatural polysaccharideoxidative stress

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