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A Panoramic View of Ferroptosis in Cardiovascular Disease
Xihao Cheng1, Chao Yu1, Xinquan Yang1
1The Second Affiliated Hospital, The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou, China.
Insights
Ferroptosis, a cell death form, is key in cardiovascular diseases (CVD). Targeting ferroptosis offers new therapeutic strategies for CVD prevention and treatment.
Area of Science:
- Biomedical Science
- Cardiovascular Research
- Cell Death Mechanisms
Background:
- Cardiovascular disease (CVD) is a major global health burden.
- Ferroptosis, distinct from other cell death types, involves iron-dependent lipid peroxidation.
- Emerging research illuminates ferroptosis's role in CVD physiology and pathology.
Purpose of the Study:
- To provide a comprehensive overview of ferroptosis in CVD.
- To highlight the pathogenic mechanisms of ferroptosis in various cardiovascular conditions.
- To discuss future therapeutic strategies targeting ferroptosis for CVD.
Main Methods:
- Literature review of ferroptosis and CVD research.
- Analysis of metabolic pathways regulating ferroptosis (iron, lipid, redox).
- Examination of ferroptosis modulators in preclinical and clinical studies.
Main Results:
- Ferroptosis is implicated in diverse CVDs like cardiomyopathy, heart failure, and atherosclerosis.
- Metabolic dysregulation, particularly in iron and lipid metabolism, drives ferroptosis in CVD.
- Ferroptosis modulators show promise for CVD prevention and treatment.
Conclusions:
- Ferroptosis plays a significant pathogenic role in cardiovascular diseases.
- Targeting ferroptosis presents a promising therapeutic avenue for managing CVD.
- Further research is crucial to fully leverage ferroptosis modulation for clinical applications in CVD.
Background:
Cardiovascular disease (CVD) remains the leading cause of disease burden worldwide. Ferroptosis, an iron-dependent form of programmed cell death, is characterized by the lethal accumulation of lipid peroxidation, which is morphologically, biochemically, and genetically distinct from apoptosis, necrosis, and pyroptosis. Emerging evidence provides exciting novel insights to allow for a deeper understanding of the physiology and pathology of ferroptosis in CVD.
Summary:
The rapidly evolving insights into ferroptosis have revealed its role in the pathogenesis of diverse forms of CVD, including cardiomyopathy, heart failure, atherosclerosis, pulmonary arterial hypertension, and cerebrovascular disease. Various types of metabolic pathways are involved in the regulation of ferroptosis, including iron metabolism, lipid metabolism, and redox metabolism. Modulators of ferroptosis, such as several clinical drugs, preclinical compounds, and other emerging materials, have been applied as promising approaches in the prevention and treatment of CVD.
Key Message:
In this review, we provide a 360 degree view of the latest progress in the field of ferroptosis in CVD, highlight the pathogenic role of ferroptosis in CVD, and also discuss the importance and future directions of targeting ferroptosis in CVD.
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