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Related Experiment Video

Updated: Jul 21, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Kidney Involvement in Autoinflammatory Diseases.

Changming Zhang1, Jiahui Peng2, Zhihong Liu1,2

  • 1National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Kidney Diseases (Basel, Switzerland)
|July 27, 2023
PubMed
Summary
This summary is machine-generated.

Autoinflammatory diseases (AIDs) can cause severe kidney damage through amyloidosis and vasculitis. Early diagnosis and biologic therapies targeting inflammation are crucial for managing these renal complications.

Keywords:
AA amyloidosisAutoinflammatory diseasesKidney diseaseVasculitis

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Area of Science:

  • Immunology
  • Nephrology
  • Genetics

Background:

  • Autoinflammatory diseases (AIDs) stem from innate immune system dysregulation, causing systemic inflammation.
  • Advances in sequencing and biotechnology identify new monogenic AIDs and signaling pathways for targeted therapies.
  • The kidney is a primary target organ for inflammatory processes in AIDs.

Purpose of the Study:

  • To highlight the significant kidney manifestations associated with autoinflammatory diseases.
  • To emphasize the importance of recognizing renal complications for timely diagnosis and treatment.
  • To discuss the role of emerging therapies in managing kidney damage in AIDs.

Main Methods:

  • Review of literature on kidney involvement in various autoinflammatory diseases.
  • Analysis of pathophysiological mechanisms linking systemic inflammation to renal damage.
  • Discussion of diagnostic and therapeutic strategies for renal manifestations in AIDs.

Main Results:

  • Systemic inflammation in AIDs elevates serum amyloid A (SAA), leading to renal AA amyloidosis and kidney damage.
  • AIDs are associated with various kidney diseases, including glomerulonephritis, lupus nephritis, and renal tubular dysfunction.
  • Renal vasculitis, such as Takayasu arteritis and polyarteritis nodosa, frequently occurs in AIDs.

Conclusions:

  • Kidney manifestations, including amyloidosis and vasculitis, are common and critical complications of AIDs.
  • Awareness of these renal issues is vital for accurate diagnosis and effective treatment of AIDs patients.
  • Biologic therapies targeting cytokine-mediated inflammation show promise in reversing organ damage if initiated early.