Related Experiment Video

Updated: Jul 21, 2025

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.7K

Hypoxic Tumor-Derived Exosomal miR-199a-3p Promote Gastric Cancer Metastasis via MAP3K4

Li Li1,2, Lei Wang3, Jia-Li Yang4

  • 1General Surgery, Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.

Journal of Cancer
|July 27, 2023
PubMed

Insights

Proximal gastrectomy for upper gastric cancer can cause reflux. Various reconstruction methods are reviewed to retain stomach function and prevent esophagitis after this procedure.

Area of Science:

  • Surgical Oncology
  • Gastroenterology

Background:

  • Proximal gastrectomy is indicated for early upper gastric cancer and Siewert II gastroesophageal junction cancer.
  • This procedure can disrupt the gastroesophageal junction's anatomy and anti-reflux function.

Purpose of the Study:

  • To review indications, advantages, and disadvantages of anti-reflux reconstructions after proximal gastrectomy.
  • To discuss classic and novel reconstruction techniques.

Main Methods:

  • Literature review of surgical reconstruction methods.
  • Analysis of techniques including esophageal-gastric anastomosis, tubular esophagogastric anastomosis, muscle flap, jejunal interposition, and double-tract reconstruction.

Main Results:

  • Various reconstruction methods aim to preserve gastric function and prevent reflux esophagitis.
  • Different techniques offer distinct benefits and drawbacks for patients undergoing proximal gastrectomy.

Conclusions:

  • Anti-reflux reconstructions are crucial for maintaining function after proximal gastrectomy.
  • Advances in reconstruction techniques help mitigate complications like reflux esophagitis.
Keywords:
double-tract reconstructiongastroesophageal anastomosisjejunal interpositionmuscle flap anastomosisproximal gastrectomy

More Related Videos

A Proximal Culture Method to Study Paracrine Signaling Between Cells08:17

A Proximal Culture Method to Study Paracrine Signaling Between Cells

Published on: August 28, 2018

9.5K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.5K

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.4K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K