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Updated: Jul 21, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
07:47

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Published on: January 1, 2016

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Quorum Sensing in Gram-Negative Bacteria: Strategies to Overcome Antibiotic Resistance in Ocular Infections

Sakshi Tiwari1, Bina Gidwani2, Amber Vyas1

  • 1University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, C.G., India.

Current Molecular Medicine
|July 27, 2023
PubMed

Insights

Antibiotic resistance in ocular pathogens is a growing threat. This review explores using quorum sensing inhibitors and nanotechnology to combat resistant gram-negative bacteria in eye infections.

Area of Science:

  • Microbiology
  • Ophthalmology
  • Drug Discovery

Background:

  • Antibiotic resistance poses a significant global health threat, jeopardizing the efficacy of life-saving medications.
  • Bacteria, particularly gram-negative pathogens, develop resistance by forming biofilms, which shield them from antibiotics.
  • Ocular infections caused by antibiotic-resistant bacteria are a growing concern worldwide, posing risks to ophthalmic tissues.

Purpose of the Study:

  • To review strategies for overcoming antibiotic resistance in ocular pathogens.
  • To highlight the role of quorum sensing (QS) in bacterial virulence and biofilm formation.
  • To explore novel therapeutic approaches, including QS inhibitors and nanotechnology, for treating resistant eye infections.

Main Methods:

  • Literature review focusing on antibiotic resistance mechanisms in ocular pathogens.
  • Analysis of quorum sensing pathways in gram-negative bacteria.
  • Evaluation of nanotechnology-based drug delivery systems for ocular applications.
  • Discussion of combination therapies involving QS inhibitors and antibiotics.

Main Results:

  • Quorum sensing is crucial for biofilm development in antibiotic-resistant bacteria.
  • Gram-negative bacteria are significant contributors to challenging ocular infections.
  • Nanotechnology offers a promising approach for enhanced antimicrobial delivery and protection.
  • Combination therapies show potential for overcoming resistance and penetrating biofilms.

Conclusions:

  • Targeting bacterial communication (quorum sensing) offers a viable strategy against antibiotic resistance.
  • Nanotechnology can improve the delivery and efficacy of antimicrobials in ocular treatments.
  • Novel approaches combining QS inhibitors with antibiotics are essential for managing resistant ocular infections.
  • Overcoming limitations in ocular drug delivery is key to successful treatment of resistant infections.
Keywords:
Antibioticsantibiotic resistancebiofilmgram-negative bacteria.ocular infectionsquorum sensingquorum sensing inhibitors

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