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Related Concept Videos

Variability: Analysis01:11

Variability: Analysis

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Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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Thyroid function test variability and cardiovascular morbidity in hyperthyroidism.

Nelli Suonsyrjä1, Iina Laihia1, Heini Huhtala2

  • 1Department of Internal Medicine, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Clinical Endocrinology
|July 27, 2023
PubMed
Summary
This summary is machine-generated.

Thyroid function test variability during antithyroid drug therapy, specifically free thyroxine (fT4) levels, is linked to increased cardiovascular risks. This association persists even in patients with positive thyrotropin receptor antibodies (TRAbs).

Keywords:
Graves diseaseantithyroid agentscardiovascular diseaseshyperthyroidismthyroid function teststhyroid hormonesthyrotropin receptors

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Thyroid function test (TFT) variability during antithyroid drug (ATD) therapy is not well-studied regarding adverse health outcomes.
  • Cardiovascular morbidity is a significant concern in patients with hyperthyroidism undergoing ATD treatment.

Purpose of the Study:

  • To investigate the association between TFT variability and cardiovascular morbidity in patients treated with ATDs.
  • To identify specific TFT parameters and clinical factors influencing cardiovascular risk during ATD therapy.

Main Methods:

  • Retrospective cohort study of 394 hyperthyroid patients treated with ATDs.
  • Calculation of coefficients of variation (CVs) for follow-up TSH, fT4, and fT3 measurements.
  • Logistic regression analysis to assess associations between TFT variability, baseline factors, and cardiovascular disease-associated hospital visits.

Main Results:

  • Increased fT4 variability (fT4-CV) was an independent risk factor for cardiovascular morbidity (OR: 1.02, 95% CI: 1.01-1.04).
  • Age and male gender also increased cardiovascular risk, while positive TRAbs showed a protective effect (OR: 0.29, 95% CI: 0.14-0.61).
  • fT4 variability remained associated with cardiovascular morbidity even in patients with positive TRAbs.

Conclusions:

  • Variability in fT4 levels during ATD therapy is associated with heightened cardiovascular morbidity.
  • The association between fT4 variability and cardiovascular risk is present irrespective of TRAb status.