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Updated: Jul 21, 2025

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Endovenous ablation for venous leg ulcers.
Paris L Cai1, Louise H Hitchman1, Abduraheem H Mohamed1
1Academic Vascular Surgical Unit, Hull York Medical School, Hull University Teaching Hospitals NHS Trust, Hull, UK.
Superficial endovenous ablation combined with compression therapy significantly improves venous leg ulcer (VLU) healing. This treatment is likely cost-effective, though effects on recurrence and complications require further research.
Area of Science:
- Vascular Surgery
- Dermatology
- Wound Care
Background:
- Venous leg ulcers (VLUs) affect up to 3% of adults, causing significant morbidity and healthcare costs.
- Compression therapy is the standard treatment, but recurrence is common.
- Minimally invasive endovenous techniques offer an alternative to open surgery for VLU management.
Approach:
- A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted.
- Searched multiple databases from 1998 to April 2022 for RCTs comparing endovenous ablation plus compression versus compression alone for VLUs.
- Two RCTs with 506 participants were included, assessing ulcer healing, recurrence, quality of life, and cost-effectiveness.
Key Points:
- High-certainty evidence shows endovenous ablation with compression accelerates VLU healing compared to compression alone (HR 1.41).
- Moderate-certainty evidence suggests a probable increase in VLU healing at 90 days (RR 1.14).
- Low-certainty evidence indicates unclear effects on ulcer recurrence and thromboembolism rates.
Conclusions:
- Endovenous ablation combined with compression therapy enhances VLU healing.
- The combined approach is likely cost-effective at one year.
- Further research is needed for long-term outcomes and optimal ablation modalities.
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