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Related Concept Videos

Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

22.8K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
22.8K
Combinatorial Gene Control02:33

Combinatorial Gene Control

8.4K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.4K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

944
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
944
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

6.9K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
6.9K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

6.5K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
6.5K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

7.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.4K

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Related Experiment Video

Updated: Jul 21, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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Molecule Flips Switch on Gene Regulation

    Cancer Discovery
    |July 27, 2023
    PubMed
    Summary

    Scientists developed designer drugs to control gene expression, reprogramming cell death pathways. A prototype molecule effectively targeted BCL6, showing potential for cancer therapy by inhibiting lymphoma cell growth.

    Area of Science:

    • Molecular Biology
    • Epigenetics
    • Drug Discovery

    Background:

    • Gene expression regulation is crucial for cellular function and disease.
    • BCL6 protein is implicated in lymphoma proliferation.
    • Targeting gene expression offers therapeutic potential.

    Discussion:

    • Designer drugs can be engineered to modulate gene expression.
    • Reprogramming gene silencing and activation pathways is achievable.
    • The prototype molecule demonstrates potent BCL6 functional reprogramming.

    Key Insights:

    • A novel class of designer drugs can alter gene expression.
    • These drugs link transcription factors with epigenetic regulators.
    • The prototype molecule effectively reverses BCL6 function.

    More Related Videos

    Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells
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    Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells

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    High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
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    High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

    Published on: March 3, 2015

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    Related Experiment Videos

    Last Updated: Jul 21, 2025

    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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    Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

    Published on: September 20, 2018

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    Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells
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    Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells

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    High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
    09:44

    High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

    Published on: March 3, 2015

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    Outlook:

    • This approach holds promise for developing novel cancer therapies.
    • Further research may expand the application of these designer drugs.
    • Targeting epigenetic mechanisms offers new avenues in oncology.