Association between Intrinsic Capacity and Sarcopenia in Hospitalized Older Patients.

Area of Science:

• Gerontology
• Internal Medicine
• Public Health

Background:

• Intrinsic capacity (IC) is a key determinant of health in older adults.
• Sarcopenia, a geriatric syndrome, significantly impacts mobility and quality of life.
• Understanding the relationship between IC and sarcopenia is crucial for effective interventions.

Purpose of the Study:

• To investigate the association between intrinsic capacity (IC) and sarcopenia in hospitalized older patients.
• To identify specific IC domains related to sarcopenia and its components.

Main Methods:

• A cross-sectional study of 381 hospitalized patients aged 60 years and older.
• IC was assessed across five domains: cognition, locomotion, vitality, sensory, and psychological.
• Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria.

Main Results:

• 33.6% of patients had sarcopenia, with a median IC composite score of 1 (1, 2).
• Vitality impairment was significantly associated with a higher risk of sarcopenia.
• Higher IC composite scores correlated with increased risks of sarcopenia, low appendicular skeletal muscle mass index (ASMI), reduced handgrip strength, and slower gait speed.

Conclusions:

• More severe intrinsic capacity impairment is associated with a greater risk of sarcopenia in hospitalized older adults.
• Vitality emerged as the most critical IC domain linked to sarcopenia.
• Intrinsic capacity assessment may serve as a valuable tool for sarcopenia detection and management.