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Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

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The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
5.1K
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

14.6K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
14.6K
Organization of the Brain01:30

Organization of the Brain

858
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
858
Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

2.0K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
2.0K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

1.8K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.8K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

2.0K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
2.0K

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Related Experiment Video

Updated: Jul 21, 2025

Visualization of Cortical Modules in Flattened Mammalian Cortices
08:49

Visualization of Cortical Modules in Flattened Mammalian Cortices

Published on: January 22, 2018

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A brain-wide analysis maps structural evolution to distinct anatomical module.

Robert A Kozol1, Andrew J Conith2, Anders Yuiska1

  • 1Jupiter Life Science Initiative, Florida Atlantic University, Jupiter, United States.

Elife
|July 27, 2023
PubMed
Summary
This summary is machine-generated.

Brain evolution in Mexican cavefish shows dorsal regions contracting and ventral regions expanding. This neuroanatomical variation, studied using a detailed brain atlas, suggests developmental constraints influence brain shape and volume.

Keywords:
Astyanaxbrain atlascavefishevo/devoevolutionary biologyneuroanatomyneurodevelopmentneuroscience

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Area of Science:

  • Evolutionary biology
  • Neuroanatomy
  • Comparative genomics

Background:

  • Vertebrate brain topology is conserved, but regional neuroanatomical variation and its evolutionary drivers are less understood.
  • Studying fine-scale brain evolution is hindered by a lack of detailed anatomical analysis tools in many animal models.
  • The Mexican cavefish (Astyanax mexicanus) offers a unique system with divergent surface and cave morphs for functional genetic studies.

Purpose of the Study:

  • To investigate the evolution of brain anatomy at a regional level using the Mexican cavefish model.
  • To assess variability in brain region shape and volume across surface, cave, and hybrid populations.
  • To explore potential developmental constraints influencing neuroanatomical evolution.

Main Methods:

  • Generation of a high-resolution brain atlas for Astyanax mexicanus.
  • Application of automated computational tools to quantify regional brain volume and shape.
  • Analysis of surface fish, cavefish, and F2 hybrids to capture a range of phenotypes.

Main Results:

  • Significant neuroanatomical variation was observed, with dorsal brain regions contracting and ventral regions expanding.
  • F2 hybrid data indicate developmental constraints along the dorsal-ventral axis of the brain.
  • Similar patterns of variation in both volume and shape suggest shared underlying developmental mechanisms.

Conclusions:

  • Astyanax mexicanus is a valuable model for studying fundamental principles of brain evolution.
  • The findings provide insights into how genes influence early patterning events driving brain-wide anatomical evolution.
  • This research opens avenues for testing genetic influences on neuroanatomical diversification.