Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.1K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

7.2K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.2K
Vision01:24

Vision

53.6K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
53.6K
Glaucoma: Overview01:25

Glaucoma: Overview

623
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
623

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal Development of Macular Ganglion Cell Layer Thickness in Children: The Copenhagen Child Cohort 2000 Eye Study.

Ophthalmic epidemiology·2026
Same author

Electron-ion equilibration in superheated gold.

Nature communications·2026
Same author

Geographic Disparities in Access to Glaucoma Surgery: Lessons from a Nationwide Registry Study.

Journal of clinical medicine·2026
Same author

Extraction of Human Phenotype Ontology (HPO) Concepts from Clinical Notes Utilizing Large Language Models (LLM) with Model Context Protocol (MCP).

medRxiv : the preprint server for health sciences·2026
Same author

Retinal Neurophysiological Parameters in Young Patients With Type 1 Diabetes.

Investigative ophthalmology & visual science·2026
Same author

The impacts of high refractive errors on self-reported visual function and visual concern.

Acta ophthalmologica·2026

Related Experiment Video

Updated: Jul 21, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.4K

Visual Function and Inner Retinal Structure in Relation to Birth Factors in Autosomal Dominant Optic Atrophy.

Christina Eckmann-Hansen1,2, Toke Bek3, Birgit Sander1

  • 1Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.

Investigative Ophthalmology & Visual Science
|July 27, 2023
PubMed
Summary

Gestational age and birth weight may influence the severity of autosomal dominant optic atrophy (ADOA). This research highlights the importance of pre- and perinatal factors in understanding ADOA

More Related Videos

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.3K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.7K

Related Experiment Videos

Last Updated: Jul 21, 2025

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

19.4K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.3K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.7K

Area of Science:

  • Ophthalmology
  • Genetics
  • Neuroscience

Background:

  • Autosomal dominant optic atrophy (ADOA) exhibits significant variability in its clinical presentation.
  • Early childhood onset suggests potential pre- and perinatal influences on vision development in ADOA.
  • Mitochondrial function during fetal development, particularly in apoptosis, is a potential factor in retinal vulnerability.

Purpose of the Study:

  • To investigate the relationship between pre- and perinatal factors and visual function in individuals with ADOA.
  • To explore how birth parameters like gestational age and birth weight correlate with inner retinal layer structure and visual acuity in ADOA patients.
  • To understand the variability in ADOA expressivity by examining early developmental influences.

Main Methods:

  • A cohort study involving 142 participants with OPA1 ADOA, 62 unaffected relatives, and 90 controls.
  • Assessment of visual function (visual acuity, microperimetric sensitivity) and retinal structure (nerve fiber layer volume, ganglion cell layer volume).
  • Analysis of birth parameters including birth weight, maternal age, birth complications, and gestational age using mixed modeling.

Main Results:

  • A significant positive association was found between microperimetric sensitivity and longer gestational age in ADOA patients.
  • Interaction analyses revealed significant differences in the association between gestational age and microperimetric sensitivity between ADOA patients and controls.
  • Significant differences in the association of nerve fiber layer volume with birth weight and gestational age were observed between different OPA1 variant types.

Conclusions:

  • Gestational age and birth weight are suggested as potential factors influencing the expressivity of ADOA.
  • The findings support the inclusion of prospectively collected pre- and perinatal data in future natural history studies of ADOA.
  • Understanding these early developmental factors may lead to better prediction and management of visual outcomes in ADOA.