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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
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Human immune phenotyping reveals accelerated aging in type 1 diabetes
Melanie R Shapiro1,2, Xiaoru Dong2,3, Daniel J Perry1,2
1Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, and.
JCI Insight
|July 27, 2023
Summary
Type 1 diabetes (T1D) shows accelerated immune aging, with specific T cell phenotypes linked to disease progression. These findings offer potential biomarkers for monitoring and treating T1D.
Area of Science:
- Immunology
- Endocrinology
- Gerontology
Background:
- Immune cell composition changes throughout life, complicating disease signature identification.
- Type 1 diabetes (T1D) involves complex immune system alterations.
- Understanding age-related immune changes is crucial for disease research.
Purpose of the Study:
- To investigate immune cell phenotypes and their association with age and T1D.
- To develop a model for immune aging and assess its acceleration in T1D.
- To identify age-corrected immune signatures predictive of T1D.
Main Methods:
- Cross-sectional flow cytometry on peripheral blood from 826 individuals (T1D, relatives, autoantibody-positive, controls).
- Development of an immune age predictive model in unaffected participants.
- Application of generalized additive models for age-correction of immune and blood count data.
Main Results:
- Accelerated immune aging observed in individuals with T1D.
- 46 immune parameters associated with age, 25 with T1D, and 23 with both.
- Increased CXCR3+ and PD-1+ naive/memory T cells in T1D, indicating advanced immune aging.
Conclusions:
- Type 1 diabetes is characterized by advanced immune aging.
- Specific immune phenotypes, like altered T cell subsets, are associated with T1D.
- Identified phenotypes may serve as biomarkers for T1D monitoring and therapeutic targets.
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