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Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation.

Sara Gimondi1,2, Helena Ferreira1,2, Rui L Reis1,2

  • 13B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal.

ACS Nano
|July 27, 2023
PubMed
Summary
This summary is machine-generated.

Microfluidic systems offer advanced platforms for nanoparticle (NP) synthesis and screening in nanomedicine. These technologies enable precise control and efficient testing of NPs for improved disease treatment and diagnosis.

Keywords:
clinical translationin vitro modelsmicrofluidicsnanomedicinenanoparticles screeningnanoparticles synthesisorgan-on-a-chiporganisms-on-a-chip

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Area of Science:

  • Nanomedicine
  • Biotechnology
  • Materials Science

Background:

  • Nanoparticles (NPs) show promise in nanomedicine for disease treatment, diagnosis, and monitoring.
  • Conventional therapies have limitations, driving the need for advanced NP development and testing.
  • Precise design, production, and testing of NPs are crucial for realizing their full potential.

Purpose of the Study:

  • To review microfluidic platforms for controlled nanoparticle synthesis.
  • To discuss innovative microfluidic systems for in vitro and in vivo nanoparticle screening.
  • To explore the application of organism-on-a-chip models for NP evaluation.

Main Methods:

  • Summarizing major microfluidic platforms for controlled NP synthesis.
  • Discussing innovative microfluidic platforms for mimicking in vitro environments.
  • Reviewing microfluidic applications for small organism manipulation and immobilization.

Main Results:

  • Microfluidic systems enable controlled NP synthesis with enhanced batch-to-batch reproducibility.
  • Microfluidic devices offer versatile platforms for rapid and efficient in vitro and in vivo NP screening.
  • Organism-on-a-chip technologies show potential for advanced NP evaluation.

Conclusions:

  • Microfluidic technologies are essential for precise NP synthesis and screening in nanomedicine.
  • Challenges and future directions for microfluidic systems in NP development are critically assessed.
  • Microfluidics is poised to significantly impact nanomedicine through improved NP applications.