Senescent Stem Cell Dysfunction and Age-Related Diseases
Related Experiment Video
Updated: Jul 21, 2025

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
1Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Nankai, Tianjin, China.
Abstract:
As the body ages, it experiences a gradual decline in the functioning of cells, tissues, and systems, which eventually leads to dysfunction and increased susceptibility to disease. At the cellular level, a reduction in the activity or number of stem cells is an important feature of cell senescence, and such changes may also directly drive the aging of the organism. Thus, finding ways to prevent or even reverse stem cell senescence holds promise for the development of aging therapies in tissues and organisms. This review discusses the relationship between changes in stem cell senescence, tissues aging, and related diseases, focusing on four categories of tissue stem cells: hematopoietic stem cells, mesenchymal stromal/stem cells (MSCs), intestinal stem cells, and muscle stem cells.
More Related Videos
07:39SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Published on: June 28, 2019
08:56Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
Published on: July 12, 2022
Related Concept Videos
The Effect of Aging on Tissues
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Stem Cell Niche
Stem Cell Culture
Tissue Renewal without Stem Cells
However, failure of such a system...
Mitochondria