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Updated: Jul 21, 2025
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Electrochemically Driven Deoxygenative Borylation of Alcohols and Carbonyl Compounds
Weiyang Guan1, Yejin Chang1, Song Lin1
1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14850, United States.
Abstract:
We present a new, unified approach for the transformation of benzylic and allylic alcohols, aldehydes, and ketones into boronic esters under electroreductive conditions. Key to our strategy is the use of readily available pinacolborane, which serves both as an activator and an electrophile by first generating a redox-active trialkylborate species and then delivering the desired deoxygenatively borylated product. This strategy is applicable to a variety of substrates and can be employed for the late-stage functionalization of complex molecules.
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