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Psychoneuroimmunological Markers of Psychological Intervention in Pediatric Cancer: A Systematic Review and New

Idyatul Hasanah1, Nursalam Nursalam2, Ilya Krisnana2

  • 1Faculty of Nursing, Airlangga University, Surabaya, 60115, Indonesia; Nursing Department, STIKES Yarsi Mataram, 83115, Indonesia.

Asian Nursing Research
|July 27, 2023
PubMed

Insights

Psychological interventions show promise in managing psychoneuroimmunological markers in pediatric cancer patients. This systematic review highlights their potential and proposes an integrative model for future research on stress and immunity.

Area of Science:

  • Integrative medicine
  • Pediatric oncology
  • Psychoneuroimmunology

Background:

  • Pediatric cancer presents complex stressors impacting children's psychoneuroimmunological health.
  • Existing evidence on psychological interventions' effects on these markers is limited.
  • Understanding these interactions is crucial for improving patient outcomes.

Purpose of the Study:

  • To systematically review the effectiveness of psychological interventions on psychoneuroimmunological markers in children with cancer.
  • To develop a novel integrative model for future research in this field.

Main Methods:

  • Systematic review utilizing Scopus, PubMed, ScienceDirect, and ProQuest databases.
  • PRISMA guidelines and Rayyan application for article selection.
  • JBI critical appraisal tools and PICO Synthesis for data analysis.

Main Results:

  • 21 articles were included from 1653 initial searches.
  • Randomized controlled trials constituted the majority (57.1%) of studies.
  • Massage therapy was the most frequent intervention; few studies assessed neuroimmunological markers.

Conclusions:

  • Psychological interventions are recommended as adjuncts for managing pediatric cancer psychoneuroimmunological markers.
  • A new integrative model is proposed, illustrating stress, intervention, and neuroendocrine-immune interactions.
  • Further research is needed to validate the proposed model's components and health outcome relevance.
Abstract

Keywords:
biomarkerscancerpediatricpsychological interventionpsychoneuroimmunology

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