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Updated: Jul 21, 2025
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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
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Free Tissue Transfer in Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis
Saiuj Bhat1, Benjamin Chia2, Ian P Barry2
1Department of Plastic and Reconstructive Surgery, Royal Perth Hospital, Perth, Australia; School of Medicine, The University of Western Australia, Crawley, Australia.
Summary
Free tissue transfer is a viable option for treating severe diabetic foot ulcers, showing high flap survival and ambulation rates. However, the evidence quality is low, necessitating further research on patient selection and long-term outcomes.
Area of Science:
- Microsurgery
- Diabetic Foot Management
- Reconstructive Surgery
Background:
- Diabetic foot ulcers (DFUs) are a significant cause of morbidity and limb loss.
- Free tissue transfer (FTT) is a reconstructive option for complex DFUs.
Conclusions:
- FTT may be beneficial for select patients with recalcitrant DFUs.
- High risk of bias and very low certainty of evidence were noted.
- Further research is needed to optimize patient selection and assess long-term functional outcomes.
