Related Experiment Video
Updated: Jul 21, 2025

03:26
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
Published on: March 8, 2024
2.7K
Targeted Muscle Reinnervation to Reduce Postoperative Pain in Patients Undergoing Hindquarter Resections
Mikaela H Sullivan1, Gavin L Mills1, Hiba Saifuddin2
1Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, U.S.A.
Anticancer Research
|July 27, 2023
Summary
Pre-emptive targeted muscle reinnervation (TMR) during hindquarter amputation can reduce phantom limb pain (PLP) and neuroma pain. This technique offers an alternative to long-term pain medication dependence.
Area of Science:
- Surgical Innovation
- Pain Management
- Neuroscience
Background:
- Phantom limb pain (PLP) affects up to 90% of hindquarter amputation patients.
- Painful neuromas occur in 50% of these patients.
- Limited literature exists on targeted muscle reinnervation (TMR) for hindquarter amputations.
Approach:
- Cadaveric dissection identified accessible motor nerves (sciatic, femoral, obturator) for TMR.
- Clinical case review of patients undergoing hindquarter amputation with TMR was performed.
Key Points:
- Accessible neuroanatomy for TMR in hindquarter amputations was confirmed.
- Patients undergoing TMR used pain medication for significantly shorter durations.
- No patients reported debilitating phantom limb pain or neuroma pain post-TMR.
Conclusions:
- Pre-emptive TMR is a viable surgical option for hindquarter amputations.
- TMR can effectively limit phantom limb pain and neuroma pain.
- Consider TMR to reduce reliance on pain medications.
Related Concept Videos
Skeletal Muscle Relaxants: Therapeutic Uses
515
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
515
Peripheral Artery Disease V: Postoperative Nursing Management
12
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
12
Local Anesthetics: Clinical Application as Spinal Anesthesia
680
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
680

