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Disseminated blastomycosis treated with ketoconazole.

Southern Medical Journal

|September 1, 1986

Summary

Disseminated blastomycosis in a mother led to intrauterine transmission to her infant, who died of pulmonary blastomycosis. The mother

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Area of Science:

Mycology
Infectious Diseases
Neonatal Health

Background:

Blastomycosis is a fungal infection caused by Blastomyces dermatitidis.
Disseminated blastomycosis can affect multiple organ systems.
Intrauterine transmission of fungal infections is rare but possible.

Purpose of the Study:

To report a rare case of presumed intrauterine transmission of blastomycosis.
To highlight the potential for neonatal complications of maternal blastomycosis.
To document the treatment response in a patient with disseminated blastomycosis.

Main Methods:

Case report of a patient with disseminated blastomycosis during pregnancy.
Clinical observation of the infant's health and outcome.
Assessment of treatment efficacy based on clinical response.

Main Results:

The infant born to a mother with disseminated blastomycosis died at three weeks of age from diffuse pulmonary blastomycosis.
The infant's condition was likely due to intrauterine transmission of the fungal infection.
The mother's extensive skin lesions showed a dramatic response to ketoconazole treatment.

Conclusions:

Intrauterine transmission of blastomycosis is a potential, albeit rare, complication of maternal infection.
Disseminated blastomycosis in pregnancy poses a significant risk to the neonate.
Ketoconazole appears effective in treating disseminated blastomycosis with cutaneous involvement.

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