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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Perinatal Depression: A Review and an Update

Anne Louise Stewart1, Jennifer L Payne1

  • 1Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, PO Box 800548, Charlottesville, VA 22908, USA.

The Psychiatric Clinics of North America
|July 27, 2023
PubMed

Perinatal depression is a common psychiatric condition that has negative effects on pregnancy and infant outcomes. Screening for the condition is relatively easy and should be done routinely in all medical care of the pregnant and postpartum woman and her infant. The risk-benefit analysis favors the use of antidepressant medications during pregnancy and lactation compared with the risk of untreated maternal depression. Other, nonpharmacological treatments will be discussed as well as new treatments, including a new class of medications that act on the inhibitory GABAergic neurotransmitter system.

Keywords:
AllopregnanoloneAntenatal depressionAntidepressantsGABAergic neurotransmissionInfantLactationPerinatal depressionPostpartum depression

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