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Updated: Jul 21, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Perinatal Depression: A Review and an Update.

Anne Louise Stewart1, Jennifer L Payne1

  • 1Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, PO Box 800548, Charlottesville, VA 22908, USA.

The Psychiatric Clinics of North America
|July 27, 2023
PubMed
Summary

Perinatal depression significantly impacts maternal and infant health. Routine screening and treatment, including medication and non-pharmacological options, are recommended for pregnant and postpartum women.

Keywords:
AllopregnanoloneAntenatal depressionAntidepressantsGABAergic neurotransmissionInfantLactationPerinatal depressionPostpartum depression

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Area of Science:

  • Perinatal psychiatry
  • Maternal-fetal medicine
  • Neuropharmacology

Background:

  • Perinatal depression is a prevalent psychiatric disorder affecting pregnant and postpartum individuals.
  • Untreated maternal depression poses risks to both the mother and the developing infant.
  • Early identification and intervention are crucial for positive outcomes.

Purpose of the Study:

  • To emphasize the importance of routine screening for perinatal depression.
  • To review the risk-benefit analysis of antidepressant use during pregnancy and lactation.
  • To discuss current and emerging treatment strategies for perinatal depression.

Main Methods:

  • Literature review on perinatal depression screening and management.
  • Analysis of risk-benefit profiles for pharmacotherapy in pregnancy and lactation.
  • Exploration of non-pharmacological and novel pharmacological interventions.

Main Results:

  • Screening for perinatal depression is feasible and should be integrated into routine care.
  • The benefits of treating maternal depression often outweigh the risks associated with necessary medications.
  • New treatments targeting the GABAergic system show promise.

Conclusions:

  • Routine screening and timely treatment are essential for managing perinatal depression.
  • Antidepressant use during pregnancy and lactation is generally favorable compared to untreated depression.
  • Advancements in treatment, including novel GABAergic agents, offer new therapeutic avenues.