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Published on: April 28, 2015
Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation
1Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA; Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, WA, USA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Abstract:
Timely intervention of preventative and therapeutic measures abated a 2022 mpox global outbreak. However, the high transmissibility and unique pathological characteristics of mpox demand further investigation. Here, we discuss the potentials of human skin-on-a-chip as a valuable model for mpox disease evaluation, to achieve in-depth physiological understanding and desirable therapeutic predictive capabilities.
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