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Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos

Ramtin Farhadi1,2, Marzieh Daniali1,2, Maryam Baeeri1,2

  • 1Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Drug and Chemical Toxicology
|July 28, 2023
PubMed

Insights

Metformin protects against chlorpyrifos (CPF) pesticide-induced heart and lung damage by reducing oxidative stress and inflammation. This study shows metformin

Area of Science:

  • Toxicology and Pharmacology
  • Cardiovascular and Respiratory Research

Background:

  • Chlorpyrifos (CPF) is a widely used organophosphate pesticide with known organ-damaging effects.
  • Metformin exhibits protective properties against cellular dysfunction induced by oxidative stress and inflammation.

Purpose of the Study:

  • To investigate the protective effects of metformin on chlorpyrifos-induced damage in the heart and lungs.
  • To elucidate the mechanisms underlying metformin's modulatory impact on CPF toxicity.

Main Methods:

  • Wistar rats were treated with varying doses of metformin and CPF.
  • Analysis included oxidative stress biomarkers (ROS, MDA), inflammatory cytokines (TNF-α), HMGB1 gene expression, DNA damage, lactate levels, ADP/ATP ratio, gene expression (TRADD, TERT, KL), and histological examination of heart and lung tissues.

Main Results:

  • Metformin significantly mitigated CPF-induced impairments in heart and lung tissues.
  • The protective effects involved modulation of oxidative stress, inflammation, and DNA damage markers.

Conclusions:

  • Metformin demonstrates significant protective potential against chlorpyrifos-induced cardiorespiratory toxicity.
  • Metformin may serve as a therapeutic agent to counteract pesticide-induced organ damage.
Keywords:
ChlorpyrifosDNA damageROSmetforminoxidative stresstoxicity

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