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Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

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Medium chain length polyhydroxyalkanoates as potential matrix materials for peripheral nerve regeneration.

Rinat Nigmatullin1,2, Caroline S Taylor3, Pooja Basnett2

  • 1Higher Steaks Ltd., 25 Cambridge Science Park Rd, Milton, Cambridge CB4 0FW, UK.

Regenerative Biomaterials
|July 28, 2023
PubMed
Summary

Medium chain length polyhydroxyalkanoates (mcl-PHAs) show promise for nerve regeneration. These natural polymers support neuronal and Schwann cell growth and adhesion, with P(3HO-co-3HD) demonstrating superior performance for tissue engineering applications.

Keywords:
NG108-15Schwann cellsbiomaterialsmcl-polyhydroxyalkanoatesnerve regenerationperipheral nerve injury

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Polyhydroxyalkanoates (PHAs) are sustainable, biodegradable polymers with potential in tissue engineering.
  • Medium chain length PHAs (mcl-PHAs) possess mechanical properties suitable for nerve regeneration applications.
  • Existing synthetic polymers like PLLA have limitations in peripheral nerve repair.

Purpose of the Study:

  • To comparatively evaluate mcl-PHAs against short chain length PHAs and synthetic polyesters for nerve regeneration.
  • To assess the biocompatibility and cell interaction of mcl-PHAs with neuronal and Schwann cells.
  • To identify optimal PHA materials for peripheral nerve repair and regenerative medicine.

Main Methods:

  • Synthesis and characterization of poly(3-hydroxyoctanoate) (P(3HO)), poly(3-hydroxyoctanoate-co-3-hydoxydecanoate) (P(3HO-co-3HD)), and poly(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate) (P(3HO-co-3HD-co-3HDD)).
  • In vitro evaluation using NG108-15 neuronal cells and primary Schwann cells.
  • Assessment of cell adhesion, viability, and neurite outgrowth on PHA materials.

Main Results:

  • No cytotoxic effects were observed for mcl-PHAs on neuronal and Schwann cells.
  • All tested mcl-PHAs supported cell adhesion and viability.
  • P(3HO-co-3HD) demonstrated superior performance in supporting cell adhesion, viability, and neurite extension compared to other mcl-PHAs and P(3HB).

Conclusions:

  • mcl-PHAs are excellent biomaterials for nerve tissue engineering due to their biocompatibility and ability to promote nerve regeneration.
  • P(3HO-co-3HD) shows significant potential for clinical applications in peripheral nerve repair.
  • mcl-PHAs offer a promising alternative to synthetic polymers for enhancing nerve regeneration.