Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

213
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
213
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

311
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
311
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

251
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
251
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

276
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
276

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A BODIPY-based turn-on fluorescent probe for the selective detection of hydrogen sulfide in solution and in cells.

Talanta·2015
Same author

Analysis of sagittal balance using spinopelvic parameters in ankylosing spondylitis patients treated with vertebral column decancellation surgery.

Acta orthopaedica Belgica·2015
Same author

Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro.

Endocrinology·2015
Same author

Noncontact Monitoring of Blood Oxygen Saturation Using Camera and Dual-Wavelength Imaging System.

IEEE transactions on bio-medical engineering·2015
Same author

Digital human modeling and its applications: Review and future prospects.

Journal of X-ray science and technology·2015
Same author

Capture-based high-coverage NGS: a powerful tool to uncover a wide spectrum of mutation types.

Genetics in medicine : official journal of the American College of Medical Genetics·2015

Related Experiment Video

Updated: Jul 21, 2025

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.1K

The causal associations between growth factors and constipation: a two-sample Mendelian randomization study.

Jiachen Wang1, Mingyi Yang1, Ke Xu1

  • 1Department of Joint Surgery, HongHui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Frontiers in Physiology
|July 28, 2023
PubMed
Summary

This study investigated the genetic links between growth factors (GFs) and constipation using Mendelian randomization. Several GFs were found to be genetically associated with constipation risk, suggesting potential causal relationships.

Keywords:
cell growth factorsconstipationgenome-wide association studysingle-nucleotide polymorphismstwo-sample Mendelian randomization

More Related Videos

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.1K
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

464

Related Experiment Videos

Last Updated: Jul 21, 2025

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.1K
Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.1K
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

464

Area of Science:

  • Genetics
  • Gastroenterology
  • Biochemistry

Background:

  • Constipation is a common condition with multifactorial causes.
  • While some growth factors (GFs) are linked to constipation, causal relationships remain under-explored.
  • Genome-wide association studies (GWAS) provide valuable genetic data for exploring such associations.

Purpose of the Study:

  • To systematically investigate the potential causal associations between circulating growth factor levels and constipation.
  • To leverage two-sample Mendelian randomization (MR) to analyze genetic data from large-scale GWAS.
  • To identify specific growth factors that may influence constipation risk.

Main Methods:

  • Two-sample Mendelian randomization (MR) analysis was performed using publicly available GWAS data.
  • Genetic variants associated with growth factor levels (exposure) and constipation (outcome) were identified.
  • Multiple MR methods (IVW, MR-Egger, weighted median) and sensitivity analyses were employed to ensure robust findings.

Main Results:

  • Inverse associations were observed between NGFI-A-binding protein 2, vascular endothelial growth factor receptor 2, proheparin-binding epidermal growth factor, platelet-derived growth factor AA, and vascular endothelial growth factor121 with constipation.
  • Positive associations were found between fibroblast growth factor 7 and transforming growth factor beta receptor II levels and constipation.
  • Sensitivity analyses supported the robustness of the identified genetic associations.

Conclusions:

  • This study provides genetic evidence supporting associations between specific growth factors and constipation risk.
  • Findings suggest potential biological pathways linking growth factors to the pathophysiology of constipation.
  • Further research is warranted to elucidate the precise mechanisms and clinical implications.