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Adherence, belief, and knowledge about oral anticoagulants in patients with bioprosthetic heart valve replacement: a

Yun-Xia Ni1, Lu-Lu Liu2, Huang Feng3

  • 1Department of Cardiology, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China.

Frontiers in Pharmacology
|July 28, 2023
PubMed

Insights

Patients with mechanical heart valves (BHV) show low oral anticoagulant adherence. Improving patient knowledge and beliefs about medication is key to enhancing adherence after BHV replacement.

Area of Science:

  • Cardiology
  • Pharmacology
  • Patient Adherence Research

Background:

  • Mechanical heart valve (BHV) replacement procedures are increasing.
  • Optimal oral anticoagulant therapy is crucial post-BHV replacement.
  • Understanding adherence barriers and facilitators is vital.

Purpose of the Study:

  • To assess oral anticoagulant adherence in BHV replacement patients.
  • To investigate the mediating role of medication beliefs.
  • To explore the link between knowledge and adherence.

Main Methods:

  • Cross-sectional study with 323 BHV replacement patients.
  • Utilized Morisky Medication Adherence Scale, Beliefs about Medicines Questionnaire, and Knowledge of Anticoagulation Questionnaire.
  • Mediation analysis using Hayes's PROCESS macro.

Main Results:

  • Only 35.6% of patients reported high adherence to oral anticoagulants.
  • Knowledge and necessity beliefs positively influenced adherence.
  • Concern beliefs negatively correlated with adherence, with medication belief mediating the knowledge-adherence relationship.

Conclusions:

  • Patients with BHV replacement exhibit suboptimal oral anticoagulant adherence.
  • Interventions should focus on enhancing patient knowledge and beliefs regarding anticoagulation.
  • Addressing medication beliefs is crucial for improving adherence outcomes.

Keywords:
bioprosthetic heart valve replacementknowledgemediation effectmedication adherencemedication belieforal anticoagulation

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