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Updated: Jul 21, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Is the standardized antibiotic administration ratio (SAAR) ready for prime time?
Yi Guo1, Elizabeth Dodds Ashley2
1Department of Pharmacy, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
The standardized antibiotic administration ratio (SAAR) allows hospitals to compare antibiotic use and target interventions. Utilizing SAAR with stewardship programs improves antibiotic prescribing practices.
Area of Science:
- Infectious Diseases
- Healthcare Quality Improvement
- Pharmacology
Background:
- The standardized antibiotic administration ratio (SAAR) is a metric for comparing antibiotic use (AU) across healthcare settings.
- The National Healthcare Safety Network (NHSN) collects AU data from numerous institutions.
- Effective antimicrobial stewardship is crucial for combating resistance and improving patient outcomes.
Discussion:
- SAAR facilitates the identification of specific areas and antimicrobial agents requiring stewardship interventions.
- Comparing AU data through SAAR helps pinpoint variations in prescribing patterns.
- Integrating SAAR with existing stewardship programs enhances their impact and efficiency.
Key Insights:
- SAAR provides a standardized framework for evaluating and comparing antibiotic consumption.
- The metric aids in targeting interventions to the most impactful areas within hospitals.
- Meaningful utilization of SAAR supports data-driven antimicrobial stewardship.
Outlook:
- Continued adoption of SAAR can lead to more consistent and effective antimicrobial stewardship globally.
- Further research can explore advanced applications of SAAR in personalized medicine and public health surveillance.
- Optimizing SAAR reporting and analysis will be key to maximizing its benefits in clinical settings.
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