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Updated: Jul 21, 2025
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
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Improving antibiotic utilization through an outpatient stewardship initiative
Kayla M Hiryak1, Geena A Kludjian2, Jason C Gallagher3
1Population Health/Enabling Services, Lehigh Valley Health Network, Allentown, Pennsylvania.
Summary
Pharmacist review of antibiotic prescriptions at hospital discharge significantly reduces drug-related problems. This antimicrobial stewardship program improves outpatient antibiotic prescribing safety.
Area of Science:
- Pharmacy
- Infectious Diseases
- Pharmacotherapy
Background:
- Antibiotic prescribing errors are frequent during hospital discharge.
- Inadequate outpatient antibiotic management can lead to treatment failures and resistance.
Purpose of the Study:
- To evaluate the impact of a pharmacist-driven antimicrobial stewardship program on discharge antibiotic prescriptions.
- To identify and intervene in drug-related problems within these prescriptions.
Main Methods:
- A pharmacist-led antimicrobial stewardship program was implemented.
- Prescriptions were reviewed before transmission to community pharmacies.
- Drug-related problems and interventions were documented.
Main Results:
- Drug-related problems were identified in 48 out of 149 (32.2%) patient prescriptions.
- A total of 55 interventions were made to correct prescribing errors.
- The program demonstrated a high rate of identifying and resolving issues.
Conclusions:
- Pharmacist review at hospital discharge is effective in improving outpatient antimicrobial prescribing.
- Antimicrobial stewardship programs play a crucial role in medication safety post-discharge.
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