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Updated: Jul 21, 2025

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues
Shengping Zhang1,2,3, Luis M De Leon Rodriguez2, Freda F Li2,4
1Center for Translational Medicine, Shenzhen Bay Laboratory New Zealand.
Abstract:
Peptide and protein selective modification at tyrosine residues has become an exploding field of research as tyrosine constitutes a robust alternative to lysine and cysteine-targeted traditional peptide/protein modification protocols. This review offers a comprehensive summary of the latest advances in tyrosine-selective cleavage, functionalization, and conjugation of peptides and proteins from the past three years. This updated overview complements the extensive body of work on site-selective modification of peptides and proteins, which holds significant relevance across various disciplines, including chemical, biological, medical, and material sciences.
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