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Related Experiment Video

Updated: Jul 21, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Stool-Based Colorectal Cancer Screening Test Performance Characteristics in Those With and Without Hemorrhoids.

Derek W Ebner1, David Rushlow2, Joshua Mou3

  • 1Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

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Hemorrhoids do not impact colorectal cancer screening tests like FIT and multitarget stool DNA. These noninvasive stool tests remain effective for CRC screening, even with asymptomatic hemorrhoids.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Diagnostic Medicine

Background:

  • Colorectal cancer (CRC) screening relies on noninvasive stool tests.
  • Hemorrhoids are common and may affect test accuracy.
  • Evaluating hemorrhoid impact on CRC screening tests is crucial.

Purpose of the Study:

  • To assess the influence of hemorrhoids on the performance of fecal immunochemical test (FIT) and multitarget stool DNA (mt-sDNA) for CRC screening.

Main Methods:

  • Retrospective cohort study analyzing test characteristics (sensitivity, specificity, predictive values).
  • Patients were stratified based on hemorrhoid status recorded during colonoscopy.
  • FIT and mt-sDNA performance was compared between patients with and without hemorrhoids.

Main Results:

  • Hemorrhoids were present in 51.7% of the cohort.
  • No statistically significant differences in FIT or mt-sDNA performance were observed based on hemorrhoid status.
  • Sensitivity and specificity for both FIT and mt-sDNA remained comparable regardless of hemorrhoid presence.

Conclusions:

  • Asymptomatic hemorrhoids do not negatively affect the performance of FIT and mt-sDNA for CRC screening.
  • FIT and mt-sDNA are reliable options for CRC screening, irrespective of hemorrhoid status, in the absence of overt bleeding.