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Updated: Jul 21, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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Extrasynaptic localization is essential for α5GABA A receptor modulation of dopamine system function.

Alexandra M McCoy, Thomas D Prevot, Md Yeunus Mian

    Biorxiv : the Preprint Server for Biology
    |July 28, 2023
    PubMed
    Summary

    Extrasynaptic Gamma-Aminobutyric Acid type A receptors (GABA A R) are crucial for modulating dopamine system function. Shifting these receptors to the synapse prevents the therapeutic effects of α5-positive allosteric modulators (α5-PAMs), impacting potential antipsychotic treatments.

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