Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A system capable of verifiably and privately screening global DNA synthesis.

National science review·2026

Same author

Increasing the Effective Gene Drive Homing Rate by Targeting the Haploinsufficient Spermatogenesis Gene <i>Klhl10</i>.

The CRISPR journal·2026

Same author

QuantumPDB: A Workflow for High-Throughput Quantum Cluster Model Generation from Protein Structures.

Journal of chemical information and modeling·2026

Same author

Heritable immunization of mice against Lyme disease enables ecological disease prevention.

Nature communications·2026

Same author

Non-invasive ovulation tracking enables genetic engineering in wild rodents.

Cell reports methods·2026

Same author

Without safeguards, AI-Biology integration risks accelerating future pandemics.

Frontiers in microbiology·2026

Search research articles

Related Experiment Video

Updated: Jul 21, 2025

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Published on: January 12, 2024

PyLabRobot: An Open-Source, Hardware Agnostic Interface for Liquid-Handling Robots and Accessories.

Rick P Wierenga^1,2, Stefan Golas², Wilson Ho^2,3

¹Leiden University, Leiden, the Netherlands.

Biorxiv : the Preprint Server for Biology

|July 28, 2023

Summary

PyLabRobot is an open-source Python interface for programming various liquid handling robots. This cross-platform tool enhances laboratory automation by enabling universal control and method sharing across different robotic systems.

Keywords:

Liquid handling robots laboratory automation open source standardization

More Related Videos

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot

Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot

Published on: October 28, 2021

Related Experiment Videos

Last Updated: Jul 21, 2025

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Published on: January 12, 2024

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot

Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot

Published on: October 28, 2021

Area of Science:

Laboratory Automation
Robotics Software

Background:

Proprietary programming interfaces for liquid handling robots limit interoperability and hinder scientific collaboration.
Current systems often require specialized software for each robot model, creating development bottlenecks.

Approach:

Developed PyLabRobot, an open-source, cross-platform Python interface for programming diverse liquid handling robots.
Created a universal command set and standardized representations for labware and deck layout.
Ensured extensibility for integration with various robotic platforms operating in Cartesian coordinate systems.

Key Points:

PyLabRobot supports multiple robot models, including Hamilton STARs, Tecan EVOs, and Opentron OT-2s.
The interface facilitates method sharing and collaborative development in laboratory automation.
Validated through unit tests and application demonstrations like a browser-based simulator and calibration tools.

Conclusions:

PyLabRobot offers a flexible and open programming environment for laboratory automation.
This interface overcomes limitations of proprietary systems, promoting wider adoption and innovation in automated liquid handling.