Related Experiment Videos
[Monensin/sulfachlorpyrazine poisoning in turkeys]
Tijdschrift Voor Diergeneeskunde
|July 15, 1986
Summary
A potential interaction between monensin and sulphachlorpyrazine in turkey feed caused paralysis and increased mortality, especially in females. Symptoms resolved when the feed was changed, indicating a feed-related issue.
Area of Science:
- Veterinary Medicine
- Animal Nutrition
- Toxicology
Context:
- Paralysis observed in seven-week-old turkeys post-administration of sulphachlorpyrazine for coccidiosis.
- Higher incidence of paralysis noted in female turkeys separated from males.
Purpose:
- To investigate the cause of paralysis and mortality in turkeys.
- To assess the potential role of feed composition and drug interactions.
Summary:
- Turkeys exhibited paralysis and increased mortality (1.7% males, 11.2% females) linked to sulphachlorpyrazine and monensin in feed.
- Feed contained 122 ppm monensin, exceeding the labeled 100 ppm.
- Symptoms ceased upon replacement with a new feed batch, suggesting a feed-related toxicity or interaction.
Impact:
- Highlights the risk of drug interactions in poultry medication.
- Emphasizes the importance of accurate feed formulation and quality control.
- Provides insights into differential susceptibility between sexes in toxicological studies.