Related Experiment Video
Updated: Jul 21, 2025
12:04
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
Published on: June 24, 2019
9.6K
Cdc42 mobility and membrane flows regulate fission yeast cell shape and survival
David M Rutkowski1, Vincent Vincenzetti2, Dimitrios Vavylonis1
1Department of Physics, Lehigh University, Bethlehem PA, USA.
Biorxiv : the Preprint Server for Biology
|July 28, 2023
Summary
Cellular polarization relies on Cdc42 GTPase activation and membrane flow. Lowering Cdc42 mobility impairs polarization, but depleting GTPase-activating proteins (GAPs) rescues viability, revealing flow
Area of Science:
- Cell biology
- Systems biology
- Biophysics
Background:
- Cdc42 GTPase activation drives polarized exocytosis and membrane flows.
- Membrane flows influence the distribution of membrane-associated proteins.
- Understanding self-organization in Cdc42 secretion-polarization systems is crucial.
Conclusions:
- Membrane flows are integral to Cdc42-driven pattern formation.
- Cdc42 mobility is a critical factor regulating polarization.
- The balance between Cdc42 activity and GAP regulation is essential for cell viability and polarization.
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