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Updated: Jul 21, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Published on: June 14, 2016

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DNA damage and nuclear morphological changes in cardiac hypertrophy are mediated by SNRK through actin

Paulina Stanczyk1,2,3, Yuki Tatekoshi1,3, Jason S Shapiro1,3

  • 1Division of Cardiology, Department of Medicine, and Feinberg Cardiovascular and Renal Research Institute, Northwestern University School of Medicine, Chicago, IL, USA.

Biorxiv : the Preprint Server for Biology
|July 28, 2023
PubMed
Summary

SNF1-related kinase (SNRK) regulates cardiomyocyte nuclear structure and DNA damage response (DDR). Loss of SNRK worsens cardiac hypertrophy by disrupting actin polymerization and nuclear morphology, suggesting SNRK/DSTN interaction as a therapeutic target.

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