Related Experiment Video
Updated: Aug 8, 2026

11:42
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
9.5K
Laryngeal Sarcomatoid Carcinoma With Rhabdomyoblastic Differentiation: A Potential Pitfall for Misdiagnosis As
Billie Shine1, Juan Carlos Alvarez Moreno1, Orly Coblens2
1Pathology, University of Texas Medical Branch, Galveston, USA.
Cureus
|July 28, 2023
Summary
Sarcomatoid carcinoma (SC) of the larynx, a rare squamous cell carcinoma subtype, can present with challenging diagnoses. This case highlights the importance of considering SC even with a predominant spindle cell component and rhabdomyoblastic features.
Area of Science:
- Oncology
- Pathology
- Head and Neck Surgery
Background:
- Sarcomatoid carcinoma (SC) of the larynx is a rare variant of squamous cell carcinoma.
- It is characterized by the presence of both carcinomatous and sarcomatous components, potentially including heterologous elements.
- Rhabdomyosarcomatous differentiation within laryngeal SC is exceptionally uncommon and poses diagnostic challenges, especially when the epithelial component is inconspicuous.

