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New semiconducting polymers (SPs) overcome fluorescence quenching for enhanced near-infrared-II (NIR-II) imaging and photothermal therapy. These aggregation-induced emission polymers offer improved tumor treatment and imaging capabilities.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Semiconducting polymers (SPs) are promising for near-infrared-II (NIR-II) fluorescence imaging and photothermal therapy.
  • Traditional SPs suffer from fluorescence quenching in aggregate states due to π-π stacking, limiting their application.
  • Aggregation-induced emission (AIE) offers a strategy to enhance aggregate-state fluorescence.

Purpose of the Study:

  • To develop novel SPs with tunable photophysical properties and enhanced NIR-II fluorescence for imaging-guided photothermal therapy.
  • To address fluorescence quenching in SP aggregates using molecular engineering and AIE.
  • To create water-dispersible SP nanoparticles for efficient in vitro and in vivo applications.

Main Methods:

  • Precise molecular engineering via block copolymerization of planar and twisted monomers.
  • Ternary copolymerization to synthesize a series of new SPs.
  • Fabrication of water-dispersible nanoparticles from the optimal copolymer (SP2).

Main Results:

  • The optimal copolymer (SP2) exhibits strong light absorption, good NIR-II quantum yield, and aggregation-induced emission characteristics.
  • SP2 nanoparticles demonstrate balanced NIR-II fluorescence brightness and photothermal conversion efficiency.
  • SP2 nanoparticles show efficient photothermal therapy, distinguished NIR-II imaging, tumor accumulation, and biocompatibility in vivo.

Conclusions:

  • The developed block copolymers effectively integrate planar and twisted segments to tune SP properties.
  • SP2 nanoparticles are highly effective for NIR-II fluorescence imaging-guided photothermal therapy.
  • This approach provides a versatile platform for developing advanced SPs for biomedical applications.