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MicroRNA‑378: An important player in cardiovascular diseases (Review)
Huan Wang1, Jingjing Shi1, Jiuchong Wang1
1Department of Cardiovascular, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China.
Insights
MicroRNA-378 (miR-378) plays a key role in cardiovascular diseases (CVDs) like heart failure. This review summarizes miR-378
Area of Science:
- Cardiovascular Medicine
- Molecular Biology
- Genetics
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality.
- Understanding genetic and molecular mechanisms is crucial for effective CVD prevention and treatment.
- MicroRNAs (miRs) are increasingly recognized for their roles in CVD pathogenesis.
Approach:
- This review synthesizes existing literature on microRNA-378 (miR-378) and CVD.
- It examines the specific roles and molecular mechanisms of miR-378 in various cardiovascular conditions.
- The aim is to provide a comprehensive overview for future research.
Key Points:
- miR-378 is implicated in the pathological processes of myocardial infarction, heart failure, and coronary heart disease.
- The review consolidates findings on how miR-378 influences CVD development.
- It highlights the need for a deeper understanding of miR-378's functions in cardiovascular health.
Conclusions:
- miR-378 is a significant factor in the development of cardiovascular diseases.
- Further research into miR-378 mechanisms can inform novel therapeutic strategies for CVD.
- This review serves as a foundation for targeted interventions against cardiovascular conditions.
Abstract:
Cardiovascular disease (CVD) is a common chronic clinical condition and is the main cause of death in humans worldwide. Understanding the genetic and molecular mechanisms involved in the development of CVD is essential to develop effective prevention strategies and therapeutic measures. An increasing number of CVD‑related genetic studies have been conducted, including those on the potential roles of microRNAs (miRs). These studies have demonstrated that miR‑378 is involved in the pathological processes of CVD, including those of myocardial infarction, heart failure and coronary heart disease. Despite the potential importance of miR‑378 CVD, a comprehensive summary of the related literature is lacking. Thus, the present review aimed to summarize the findings of previous studies on the roles and mechanisms of miR‑378 in a variety of CVDs and provide an up‑to date basis for further r research targeting the prevention and treatment of CVDs.
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