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Updated: Aug 11, 2026

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Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
[Frequency of acrocentric chromosome associations in a long-term human lymphocyte culture]
Tsitologiia I Genetika
|May 1, 1986
Abstract:
The frequency of acrocentric chromosome associations (ACA) in the long-term culture of lymphocytes progressively decreases by 25% (on the average) for one mitotic cycle. As a result proliferous lymphocytes after 3-4 divisions contain either no associations or not more than 2 associating acrocentrics. The diversity of the peripheral blood lymphocytes as to the frequency of ACA in the first mitosis is connected with their different proliferative activity in the organism.
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